Cellular & Mitochondrial Optimization Panel

Cellular & Mitochondrial Optimization Panel

A comprehensive organic acids and oxidative stress test for cellular energy, resilience, and longevity

See how your cells actually perform — and where your energy is leaking.

Your energy, focus, metabolism, mood, and long-term vitality all trace back to one place: how well your cells produce energy and defend themselves against daily wear. When those systems run smoothly, you feel sharp, resilient, and capable. When they don't, the signs show up as fatigue that doesn't lift with sleep, brain fog, slow recovery, stubborn weight, mood swings, or a general sense that your body isn't keeping up with your life.

The Cellular & Mitochondrial Optimization Panel from DeNovo Longevity is a next-generation organic acids test (OAT) combined with comprehensive oxidative stress analysis — bringing the most important drivers of cellular performance into a single, organized view. Organic acids are the metabolic byproducts your cells leave behind as they generate energy, process nutrients, and respond to microbial activity. Reading them is one of the most direct ways to see how your biology is actually functioning, not just what's circulating in your blood.

What this panel reveals

This is a systems-level look at how your cells are working right now, mapping six interconnected areas of cellular health through organic acid and oxidative stress markers:

• Mitochondrial energy production — Organic acids from the Krebs cycle, fatty-acid oxidation, glycolysis, and ketone pathways reveal exactly where energy production is efficient and where it's slowing down. This is where fatigue, stamina, and metabolic flexibility are won or lost.
• Oxidative and nitrative stress — Measurable damage markers across your lipids (MDA, 4-HNE, isoprostanes), proteins (dityrosine, nitrotyrosine), and DNA/RNA (8-OHdG, 8-nitroguanine) show how much free-radical wear your cells are absorbing. Elevated markers point to accelerated cellular aging and reduced resilience.
• Detoxification capacity — How well your cells are processing and clearing metabolic byproducts, with insight into glutathione status and key detox intermediates like pyroglutamic acid and orotic acid.
• Microbial metabolites — Organic acid byproducts from yeast, bacterial, and clostridia-related activity that can quietly drive inflammation, brain fog, and energy drops.
• Nutrient utilization at the cellular level — Functional organic acid markers showing whether B-vitamins, antioxidants, and other cofactors are actually being put to work where it counts.
• Antioxidant genetics — Inherited variants in genes like SOD2, GPX1, CAT, and GSTP1 that shape how well you neutralize oxidative damage, giving context to your current results and what your body is up against long-term.

Who this panel is for

This panel is built for people who want to optimize how they feel and function — and for those navigating patterns that conventional testing tends to miss. It's especially relevant if you're experiencing:

• Persistent fatigue, low stamina, or slow recovery from exercise or stress
• Brain fog, trouble focusing, or mental sharpness that comes and goes
• Mood variability, low mood, or irritability without a clear cause
• Sleep difficulties despite good sleep habits
• Stubborn weight or metabolic changes
• A history of long-term medications, chronic stress, or environmental exposures
• A goal of building cellular resilience, supporting healthy aging, and extending healthspan

It's also a strong fit if you've previously done an organic acids test (OAT) or oxidative stress panel and want a more comprehensive, longevity-focused version that integrates genetics and a broader marker set.

What's measured

Over 100 functional markers, including:

• Organic acid markers spanning mitochondrial energy, microbial overgrowth, neurotransmitter and stress chemistry, functional metabolism, and nutrient utilization
• Oxidative stress and nitrative stress markers covering lipid peroxidation, protein oxidation, and DNA/RNA damage
• Detoxification markers including glutathione-related metabolites
• Antioxidant and redox-related genetic variants for long-term context

How it works

The Cellular & Mitochondrial Optimization Panel uses urine and saliva samples collected at home — no blood draw required. Your kit ships directly to you with everything needed for collection, along with prepaid return shipping. Results are typically delivered in 2–4 weeks through your secure DeNovo Longevity portal, where you'll find your full report alongside guidance for interpreting what your cellular chemistry is telling you.

This panel is intended solely for informational and wellness purposes to help inform lifestyle choices. It is not intended for diagnostic purposes and is not a substitute for medical advice. Please consult a licensed healthcare practitioner for any questions regarding diagnosis, prevention, or treatment of any disease or health condition.